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1.
Opt Express ; 31(24): 40202-40209, 2023 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-38041326

RESUMO

The generation of intense infrared radiation with a wavelength greater than 10 µm is limited by the optical materials in traditional methods or the laser-plasma parameters of plasma-bubble methods. In this study, we propose a new method for generating an intense longitudinal radiation field of tens of GV/m. By utilizing the oscillations of the electron film on the inner surface of the micro-tube, excited by the relativistic electron beam propagating within it, it is possible to obtain tunable long-wavelength few-cycle infrared radiation, ranging from 20 to 30 µm and even longer. The radiation source is guided entirely by a relativistic electron beam and formed a stable TM propagation mode in the micro-tube. This opens up new opportunities for applications of the relativistic intensity infrared radiation to high-field physics, shorter attosecond pulses generation and charged particle acceleration.

2.
Phys Med Biol ; 68(18)2023 09 08.
Artigo em Inglês | MEDLINE | ID: mdl-37586385

RESUMO

Objective.Ultra-high-dose-rate radiotherapy, referred to as FLASH therapy, has been demonstrated to reduce the damage of normal tissue as well as inhibiting tumor growth compared with conventional dose-rate radiotherapy. The transient hypoxia may be a vital explanation for sparing the normal tissue. The heterogeneity of oxygen distribution for different doses and dose rates in the different radiotherapy schemes are analyzed. With these results, the influence of doses and dose rates on cell survival are evaluated in this work.Approach.The two-dimensional reaction-diffusion equations are used to describe the heterogeneity of the oxygen distribution in capillaries and tissue. A modified linear quadratic model is employed to characterize the surviving fraction at different doses and dose rates.Main results.The reduction of the damage to the normal tissue can be observed if the doses exceeds a minimum dose threshold under the ultra-high-dose-rate radiation. Also, the surviving fraction exhibits the 'plateau effect' under the ultra-high dose rates radiation, which signifies that within a specific range of doses, the surviving fraction either exhibits minimal variation or increases with the dose. For a given dose, the surviving fraction increases with the dose rate until tending to a stable value, which means that the protection in normal tissue reaches saturation.Significance.The emergence of the 'plateau effect' allows delivering the higher doses while minimizing damage to normal tissue. It is necessary to develop appropriate program of doses and dose rates for different irradiated tissue to achieve more efficient protection.


Assuntos
Neoplasias , Humanos , Neoplasias/radioterapia , Neoplasias/patologia , Dosagem Radioterapêutica , Oxigênio , Hipóxia , Radioterapia
3.
RSC Adv ; 13(3): 2140-2154, 2023 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-36712609

RESUMO

Yolk-shell nanoparticles (YSNs) have attracted a broad interest in the field of catalysis due to their unique structure and properties. The hollow structure of YSNs brings high porosity and specific surface areas which is conducive to the catalytic reactions. The flexible tailorability and functionality of both the cores and shells allow a rational design of the catalyst and may have synergistic effect which will improve the catalytic performance. Herein, an overview of the research progress with respect to the synthesis and catalytic applications of YSNs is provided. The major strategies for the synthesis of YSNs are presented, including hard template method, soft template method, ship-in-a-bottle method, galvanic replacement method, Kirkendall diffusion method as well as the Ostwald ripening method. Moreover, we discuss in detail the recent progress of YSNs in catalytic applications including chemical catalysis, photocatalysis and electrocatalysis. Finally, the future research and development of YSNs are prospected.

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